The Human Gut Microbiome - Free Essay Example

Sample details Pages: 3 Words: 952 Downloads: 4 Date added: 2018/12/29 Category Health Essay Type Assignment Level High school Tags: Disease Essay Did you like this example? The human gut microbiome refers to the microbes found in the human digestive tract and their genomes. It is estimated that the number of microorganisms inhabiting the gastrointestinal tract exceeds 1014 (Bull Plummer, 2014, pp. 17). Don’t waste time! Our writers will create an original "The Human Gut Microbiome" essay for you Create order The human gut microbiota is dominated by bacteria (Clemente et al, 2012, pp. 1259). Over 1000 species of microbes colonize the gut. The most abundant are Firmicutes, Actinobacteria and Bacteroidetes, others include Verrucomicrobia, Cyanobacteria, Proteobacteria and Fusobacteria (DArgenio Salvatore, 2015, pp. 98). In the esophagus, duodenum and jejunum Streptococcus dominate while Helicobacter, Veillonella, Prevotella and Streptococcus reside in the stomach. The colon harbors Bacteroides and Firmicutes while luminal microbial genera include Lactobacillus, Ruminococcus, Bifidobacterium, Enterobacteriacae, Clostridium and Streptococcus. The human gut microbiome presents many benefits to the host like protecting the host against pathogens, regulating host immunity, harvesting energy for the host and strengthening the integrity of the gut (DArgenio Salvatore, 2015, pp. 102). It also plays a role in disease due to the presence or overabundance of certain bacteria or metabolites from certain members of the gut microbiota, which may influence the hosts signaling pathways leading to disorders such as obesity or colon cancer (Bull Plummer, 2014, pp. 17). The health of the host is determined by how healthy the gut flora is. The normal human gut microbiota is involved in nutrient metabolism and in offering antimicrobial protection. The interactions of the gut microbiota with each other and with the human host influence nutrition and metabolism (Jandhyala et al, 2015, pp. 8787). The human gut microbiota obtain their nutrients from the dietary carbohydrates from the host. Bacteroides, Enterobacteria, Fecalibacterium, Bifidobacterium and Roseburia found in the colon ferments the undigested carbohydrates and the indigestible oligosaccharides, synthesizing short chain fatty acids (SCFA) (Jandhyala et al, 2015, pp. 8787). Bacteroides thetaiotaomicron metabolizes carbohydrates by expressing glycosyl transferases, polysaccharide lyases and glycoside hydrolases. SCFAs synthesized include butyrate and acetate which are rich energy sources for the host (Flint et al, 2012, pp. 583). It is also involved in protein metabolism by use of microbial proteinases and peptidases which function together with the human proteinases (Jandhyala et al, 2015, pp. 8787). The gut microbiota is also deconjugates and dehydrates primary bile a cids into secondary bile acids in the colon. This is done by Escherichia coli, Bacteroides fragilis and Bacteroides intestinalis. The human gut microbiome has the capability to confer protection to the host against infections through non- immune- and immune- mediated mechanisms (Ubeda et al, 2017, pp. 128). Non- immune- derived mechanisms of protection include the consumption and depletion of simple sugars that could be utilized by pathogenic organisms such as Escherichia coli preventing them from causing infection (Jandhyala et al, 2015, pp. 8787). Gut microbiota also confers resistance to pathogens directly by producing and releasing molecules that have bacteriostatic or bactericidal properties (Ubeda et al, 2017, pp. 128). Innate immune- derived mechanisms of protection include the use of the mucus layer whose quantity and quality is determined by the intestinal microbiota (Jandhyala et al, 2015, pp. 8787). The human gut microbiome present detrimental effects in case of an imbalance. Consequences of microbial imbalance in the gut include an increased risk of systemic metabolic diseases and chronic gastrointestinal diseases. The gut microbiota has been implicated in systemic metabolic diseases such as type 2 diabetes mellitus and obesity due to the key role they play in the process of digestion. Dysbiosis in the gut, that is gut microbial imbalance, has been shown by research to have a direct association with the pathophysiology of type 2 diabetes and obesity (Bull Plummer, 2014, pp. 17). Gut microbiota such as Firmicutes and Bacteroides that are implicated in nutrient acquisition and harvesting energy are implicated in obesity and diabetes type 2. The human gut microbiome has been implicated in chronic gastrointestinal diseases such as irritable bowel syndrome and inflammatory bowel disease. In dysbiosis, microbial imbalance, the gut facilitates the adhesion of enteric pathogens which are responsible for the symptoms associated with irritable bowel syndrome such as abdominal discomfort and change in bowel habits (Bull Plummer, 2014, pp. 17). An imbalance in gut microbiota leads to reduced bactericidal properties, thus allowing the adherence of enteric pathogens. A reduction in numbers of Firmicutes, Bacteroidetes and Proteobacteria is associated with inflammatory bowel disease. Firmicutes are responsible for the synthesis of short chain fatty acids like butyrate and acetate, which have anti- inflammatory properties, thus a reduction in their numbers increases the risk of inflammatory bowel disease (Flint et al, 2012, pp. 586). The human gut has the largest number of microbes compared to any other part of the human body. There exists a symbiotic relationship between the gut microbiota and the host. The gut microbiota functions in nutrition, metabolism and antimicrobial protection. However, when an imbalance occurs in the gut microbiota, harmful consequences such as the onset of chronic gastrointestinal diseases and an increased risk of systemic diseases occurs. It therefore becomes crucial that the balance of gut microbiota remains at healthy levels. Bibliography Bull, M.J. and Plummer, N.T., 2014. Part 1: The human gut microbiome in health and disease.? Integrative Medicine: A Clinicians Journal, 13(6), p.17. Clemente, J.C., Ursell, L.K., Parfrey, L.W. and Knight, R., 2012. The impact of the gut microbiota on human health: an integrative view. Cell, 148(6), pp.1258-1270. DArgenio, V. and Salvatore, F., 2015. The role of the gut microbiome in the healthy adult status. Clinica Chimica Acta, 451, pp.97-102. Flint, H.J., Scott, K.P., Louis, P. and Duncan, S.H., 2012. The role of the gut microbiota in nutrition and health. Nature Reviews Gastroenterology and Hepatology, 9(10), pp.577-589. Jandhyala, S.M., Talukdar, R., Subramanyam, C., Vuyyuru, H., Sasikala, M. and Reddy, D.N., 2015. Role of the normal gut microbiota. World journal of gastroenterology: WJG, 21(29), p.8787. Thursby, E. and Juge, N., 2017. Introduction to the human gut microbiota.? Biochemical Journal, 474(11), pp.1823-1836. Ubeda, C., Djukovic, A. and Isaac, S., 2017. Roles of the intestinal microbiota in pathogen protection. Clinical translational immunology, 6(2), p.e128.

Technology And You Online Cyber Bullying - 1452 Words

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Swot Analysis Mcdonalds Free Essays

Running Head: MARKETING SWOT Analysis Answer 1. The company so selected for the sake of carrying upon SWOT Analysis is McDonalds. The company is found to run its food outlets all around the globe. We will write a custom essay sample on Swot Analysis Mcdonalds or any similar topic only for you Order Now It basically deals in fast-foods. The customers serve to be the main aspect for the company. It used to collect feedback from the customers on a regular basis. The SWOT Analysis is the tool that is used from the point of developing pertinent knowledge about company’s position in the market. From this, it can improve the weak areas and can strengthen the strong aspects more and more. The information regarding company’s SWOT Analysis can be derived from Company’s website, annual reports, books, articles and journals. All these prove to be effective from the point of developing knowledge about its strength, weakness, threats and opportunities (McDonald’s Corporation: The Past, Present, and Future, n. d. ). The strength of the company is that it is operating in accordance with various cultures. It serves to be a socially responsible company and actively work for community’s betterment. It is also placed on a great position under Fortune ranking list. The weaknesses linked with the company are that it failed to move towards pizza market. In addition to this, it needs to capitalize on the trend towards organic foods as well. The changing preferences of the customers also pose a problem in front of the company. The company understands customer’s value in business and that is why asking them regularly for more improvements. The health of the customers is taken into account with due effect and this makes it high (McDonalds, 2011). It serves to be the opportunities for the company. The threats are that the company faces intense competition and this makes things impossible. At the same time, it is also important to see to it that all these things need to be considered from the point of indentifying company’s actual position. The SWOT Analysis related to the company can be easily found out. But it seems to be very much general in approach. The point is to derive best possible information. The data and all other relevant information are not available easily while writing up SWOT Analysis for a company (Meldrum McDonald, 007). Answer 2. The SWOT Analysis is being conducted by taking information from books, company’s website, articles etc. All these altogether supports a lot in making things carried upon effectively. The information is being collectively taken from all these sources. The best possible information can be derived from books and articles. Actually, things are quite understandable and comprehensible. With this, it becomes quite easy to un derstand importance of things in a far better mode. The steps that are being adopted for checking as to information are valid or reliable or not. It is important to arrive at a better conclusion with the help of accumulating information from the authentic sources. The sources so utilized need to be effective and valuable so that interpretations can also be made properly and successfully. In addition to this, SWOT Analysis can be performed and carried out effectively as well (Our Company, 2011). Answer 3. The manager of the company is required to carry upon strategic decisions on the basis of company’s position. The SWOT Analysis so carried upon leads to make things effective and successful in approach. The information so derived online seems to be somewhat ineffective in approach. It would be better to go for developing more knowledge from some better sources. With this, it is for sure that decision-making can be made effective and good in approach. The situations need to be analyzed with due effect as well. It would make manager confident as well as self-assured from the point of carrying upon business practices in a far better way. The other relevant sources that can be used for the sake of completing SWOT analysis for the company are that proper studies and company’s previous records need to be examined and investigated with due respect. It would lead to make things effective and appropriate for the company as well (McDonalds Corporation, n. d. ). References McDonald’s Corporation: The Past, Present, and Future. (n. d. ). Retrieved March 15, 2011, from http://2myprofessor. com/Common/Sample%20Projects/McDonald%27s_Corporation. PDF McDonalds. (2011). Retrieved March 15, 2011, from http://www. mcdonalds. com/us/en/home. html McDonalds Corporation. (n. d. ). How to cite Swot Analysis Mcdonalds, Papers